MAFbx, MuRF1, and the stress-activated protein kinases are upregulated in muscle cells during total knee arthroplasty
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چکیده
منابع مشابه
MAFbx, MuRF1, and the stress-activated protein kinases are upregulated in muscle cells during total knee arthroplasty.
Total knee arthroplasty (TKA) is the most common and a cost-effective surgical remediation for older adults with long-standing osteoarthritis. In parallel with the expanding population of older adults, the number of TKAs performed annually is projected to be 3.48 million by 2030. During this surgery, a tourniquet is used to stop blood flow to the operative leg. However, the molecular pathways t...
متن کاملTRANSLATIONAL PHYSIOLOGY MAFbx, MuRF1, and the stress-activated protein kinases are upregulated in muscle cells during total knee arthroplasty
Bailey AN, Hocker AD, Vermillion BR, Smolkowski K, Shah SN, Jewett BA, Dreyer HC. MAFbx, MuRF1, and the stress-activated protein kinases are upregulated in muscle cells during total knee arthroplasty. Am J Physiol Regul Integr Comp Physiol 303: R376–R386, 2012. First published July 3, 2012; doi:10.1152/ajpregu.00146.2012.—Total knee arthroplasty (TKA) is the most common and a cost-effective sur...
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The hypothesis of the present study was that exposure of differentiated muscle cells to agonists of the AMP-activated protein kinase (AMPK) would increase the mRNA content of the muscle-specific ubiquitin ligases muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1). C(2)C(12) cells were incubated with incremental doses of 5-aminoimidazol-4-carboximide ribonucleoside (AICAR) or metformi...
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Muscle atrophy in many conditions share a common mechanism in the upregulation of the muscle-specific ubiquitin E3-ligases atrophy gene-1/muscle atrophy F-box (Atrogin-1/MAFbx) and muscle ring-finger protein 1 (MuRF1). E3-ligases are part of the ubiquitin proteasome pathway utilized for protein degradation during muscle atrophy. In this study, we provide new data to show that this is not the ca...
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Objective: The aim of this study was to validate the well-recognized outcome measure instruments (Medical Outcome Study Short Form-SF-36, Western Ontario and McMaster University Osteoarthritis Index-WOMAC, McMaster Toronto Arthritis Patient Preference Disability Questionnaire-MACTAR) for patients who had undergone total knee arthroplasty in Iran, with its cultural and ethnic differences and com...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2012
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00146.2012